Long span DNA paired-end-tag (DNA-PET) sequencing strategy for the interrogation of genomic structural mutations and fusion-point-guided reconstruction of amplicons.
Structural variations (SVs) contribute significantly to the variability of the human genome and extensive genomic rearrangements RWgift are a hallmark of cancer.While genomic DNA paired-end-tag (DNA-PET) sequencing is an attractive approach to identify genomic SVs, the current application of PET sequencing with short insert size DNA can be insuffic